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dc.contributor.author Simbiri, K.O.
dc.contributor.author Murakami, M.
dc.contributor.author Feldman, M.
dc.contributor.author Steenhoff, A.P.
dc.contributor.author Nkomazana, O.
dc.contributor.author Bisson, G.
dc.contributor.author Robertson, E.S.
dc.date.accessioned 2010-07-24T12:10:43Z
dc.date.available 2010-07-24T12:10:43Z
dc.date.issued 2010
dc.identifier.citation Simbiri, K.O. et al (2010) Multiple oncogenic viruses identified in Ocular surface squamous neoplasia in HIV-1 patients, Infectious Agents and Cancer, Vol. 5, No. 6, pp. 1-13 en_US
dc.identifier.issn 1750-9378
dc.identifier.uri http://hdl.handle.net/10311/565
dc.description.abstract Background: Ocular surface squamous neoplasia (OSSN) is a rare cancer that has increased in incidence with the HIV pandemic in Africa. The underlying cause of this cancer in HIV-infected patients from Botswana is not well defined. Results: Tissues were obtained from 28 OSSN and 8 pterygia patients. The tissues analyzed from OSSN patients were 83% positive for EBV, 75% were HPV positive, 70% were KSHV positive, 75% were HSV-1/2 positive, and 61% were CMV positive by PCR. Tissues from pterygium patients were 88% positive for EBV, 75% were HPV positive, 50% were KSHV positive, and 60% were CMV positive. None of the patients were JC or BK positive. In situ hybridization and immunohistochemistry analyses further identified HPV, EBV, and KSHV in a subset of the tissue samples. Conclusion: We identified the known oncogenic viruses HPV, KSHV, and EBV in OSSN and pterygia tissues. The presence of these tumor viruses in OSSN suggests that they may contribute to the development of this malignancy in the HIV population. Further studies are necessary to characterize the molecular mechanisms associated with viral antigens and their potential role in the development of OSSN. en_US
dc.language.iso en en_US
dc.publisher BioMed Central Ltd. www.infectagentscancer.com/content/5/1/6 en_US
dc.subject Multiple oncogenic viruses en_US
dc.subject Ocular surface en_US
dc.subject Squamous neoplasia en_US
dc.subject HIV-1 patients en_US
dc.title Multiple oncogenic viruses identified in Ocular surface squamous neoplasia in HIV-1 patients en_US
dc.type Published Article en_US


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