Browsing Research articles (Dept of Chemistry) by Author "Simeon, K."
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Antioxidant activity of prenylated flavonoids from the West African medicinal plant Dorstenia manniiDufall, K.; Ngadjui, B.; Simeon, K.; Abegaz, B.; Croft, K. (Elsevier Science Ireland Ltd. www.elsevier.com/locate/jethpharm, NaN, 2003)[more][less]
Abstract: The antioxidant activities of three prenylated flavonoids from Dorstenia mannii (6,8-diprenyleriodictyol, dorsmanin C and dorsmanin F) were compared to the common, non-prenylated flavonoid, quercetin. The prenylated flavonoids were found to be potent scavengers of the stable free radical 1,1-diphenyl-2-picrylhydrazyl (DPPH), and are more potent than butylated hydroxy toluene (BHT), a common antioxidant used as a food additive. The prenylated flavonoids also inhibited Cu2+-mediated oxidation of human low density lipoprotein (LDL). Dose-response studies indicated that the prenylated flavonoids were effective inhibitors of lipoprotein oxidation with IC50 values <1 M and had similar inhibitory potency compared to quercetin, but was not directly related to Cu binding. Unlike quercetin, they did not show any pro-oxidant activity at high doses in the Cu2+-mediated lipoprotein oxidation system. The medicinal action of Dorstenia mannii may be related to the high concentration of potent antioxidant prenylated flavonoids in this species. URI: http://hdl.handle.net/10311/261 Files in this item: 2
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