Browsing Research articles (Dept of Chemistry) by Subject "Prenylated flavonoids"

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Antitrichomonal and antioxidant activities of Dorstenia barteri and Dorstenia convexa

Omisore, N.O.A.; Adewunmi, C.O.; Iwalewa, E.O.; Ngadjui, B.T.; Adenowo, T.K.; Abegaz, B.M.; Ojewole, J.A.; Watchueng, J. (Brazilian Journal of Medical and Biological Research. http://www.scielo.br/scielo.php?pid=0100-879X&script=sci_serial, NaN, 2005)

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Abstract:

Dorstenia barteri and D. convexa extracts and some isolated components of the former were investigated for effectiveness against Trichomonas gallinarum and compared with quercetin and quercitrin. The antioxidant activity of the extracts/compounds was also determined. The minimum lethal concentrations (MLCs) for the extract of D. barteri leaves and twigs at 24 h were found to be 15.625 and 15.625 μg/ml, respectively. However, the MLCs of the leaf and twig extract of D. convexa were 125 and 437.5 μg/ml, respectively. The prenylated and geranylated chalcones were as active as the prenylated flavones, 6- prenylapigenin and the diprenylated derivative 6,8-diprenyleridictyol. The order of the antitrichomonal activity of the compounds at 24 h was: quercetin (0.121 μg/ml) > quercitrin (0.244 μg/ml) ≥ bartericin B (0.244 μg/ml) > bartericin A (0.73 μg/ml) > stigmasterol (0.98 μg/ml) > 6,8-diprenyleridictyol = isobavachalcone = dorsmanin F (31.25 μg/ ml). D. barteri extracts, quercitrin, and bartericin A, and the prenylated flavonoids had potent antioxidant properties. The twig extract of D. barteri was more potent than the leaf extract. Moderate (EC50 >50 μg/ ml) and high (EC50 <50 μg/ml) antioxidant activities were detected in the leaf and twig extracts of D. barteri and the prenylated flavonoids. Prenylated flavonoids and the isolated compounds with antioxidant properties described here may account for the anti-inflammatory action of these extracts. The antitrichomonal and antioxidant activities shown by the extracts and compounds in this study are consistent with the ethnomedicinal and local use of the Dorstenia species studied.

URI:

http://hdl.handle.net/10311/284

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Antitrichomonal and antioxidant.pdf (2.508Mb)

Prenylated flavonoids and other constituents from the twigs of Dorstenia angusticornis (Moraceae)*

Simo, I.K.; Ngadjui, B.T.; Abegaz, B.M. (Elsevier Ltd. www.elsevier.com/locate/biochemsyseco, June 18, 2005)

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Abstract:

Dorstenia (Moraceae) is a mainly tropical genus of some 170 species (Mabberley, 1987). There are 23 species in Cameroon where a decoction of the leaves is administered for the treatment of cough, headache and stomach pain (Bouquet, 1969). The genus is made up largely of herbaceous perennials with succulent and non-succulent scrambling rhizomes (Berg et al., 1989). The twigs of Dorstenia angusticornis were collected in February 2002 from Kumba South West Province of Cameroon. Voucher specimen (No 28165/sfcam) is deposited at the National Herbarium Yaounde, Cameroon.

URI:

http://hdl.handle.net/10311/255

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Prenylated flavonoids and other constituents.pdf (1.986Mb)

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Browsing Research articles (Dept of Chemistry) by Subject "Prenylated flavonoids"

Browsing Research articles (Dept of Chemistry) by Subject "Prenylated flavonoids"

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