Browsing Chemistry by Subject "flavonoids"
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Mbaveng, A.; Ngameni, B.; Kuete, V.; Simo, I.K.; Ambassa, P.; Roy, R.; Bezabili, M.; Etoa, F.X.; Ngadjui, B.; Abegaz, B.; Meyer, J.J.M.; Lall, N.; Beng, V.P. (Elsevier Ireland Ltd. http://www.elsevier.com/wps/find/journaldescription.cws_home/506035/description#description, NaN, 2008)[more][less]
Abstract: The aim of this study was to evaluate the antimicrobial activity of the crude extract of the twigs of Dorstenia barteri (DBT) as well as that of four of the five flavonoids isolated from this extract. Gram-positive bacteria (six species), Gram-negative bacteria (12 species) and fungi (four species) were used. The agar disc diffusion test was used to determine the sensitivity of the tested samples while the well micro-dilution was used to determine the minimal inhibition concentrations (MIC) and the minimal microbicidal concentration (MMC) of the active samples. The results of the disc diffusion assay showed that DBT, isobavachalcone (1), and kanzonol C (4) prevented the growth of all the 22 tested microbial species. Other compounds showed selective activity. The inhibitory activity of the most active compounds namely compounds 1 and 4 was noted on 86.4% of the tested microorganisms and that of 4-hydroxylonchocarpin (3) was observed on 72.7%. This lowest MIC value of 19.06 g/ml was observed with the crude extract on seven microorganisms namely Citrobacter freundii, Enterobacter aerogens, Proteus mirabilis, Proteus vulgaris, Bacillus megaterium, Bacillus stearothermophilus and Candida albicans. For the tested compounds, the lowest MIC value of 0.3 g/ml (on six of the 22 organisms tested) was obtained only with compound 1, which appeared as the most active compound. This lowest MIC value (0.3 g/ml) is about 4-fold lower than that of the RA, indicating the powerful and very interesting antimicrobial potential of isobavachalcone (1). The antimicrobial activities of DBT, as well as that of compounds 1, 3, 4, amentoflavone (5) are being reported for the first time. The overall results provide promising baseline information for the potential use of the crude extracts from DBT as well as some of the isolated compounds in the treatment of bacterial and fungal infections. URI: http://hdl.handle.net/10311/234 Files in this item: 2
Antimicrobial activity of the crude.pdf (2.258Mb)license.txt (1.998Kb) -
Nindi, M.M.; Kgarebe, B.V.; Wolfender, J.L.; Abegaz, B.M. (John Wiley & Sons, Ltd., NaN, 1999)[more][less]
Abstract: Three naphthalenic derivatives, four flavonoids and two of the four anthraquinones previously isolated from the leaves of Rhamnus prinoides were successfully ionised under electrospray ionisation conditions. These compounds were subsequently detected in the leaf extract of the plant using electrospray liquid chromatography–mass spectrometry (LC–ESI–MS). The potential of LC–ESI–MS for screening a leaf extract, with the focus on the suitability of the method for assaying the bitter principle, geshoidin, of this commercially important plant, is presented. URI: http://hdl.handle.net/10311/290 Files in this item: 1
Electrospray Liquid.pdf (1.464Mb)
Now showing items 1-2 of 2