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dc.contributor.author Abegaz, B.M.
dc.contributor.author Bezabih, M.
dc.contributor.author Msuta, T.
dc.contributor.author Brun, R.
dc.contributor.author Menche, D.
dc.contributor.author Muhlbacher, J.
dc.contributor.author Bringmann, G.
dc.date.accessioned 2009-07-03T13:38:28Z
dc.date.available 2009-07-03T13:38:28Z
dc.date.issued 2002
dc.identifier.citation Abegaz, B.M. (et al) (2002) Gaboroquinones A and B and 4'-O-demethylknipholone-4'-O-β-D-glucopyranoside, phenylanthraquinones from the roots of Bulbine frutescens, Journal of natural products, vol. 65, no. 8, pp. 1117-1121 en_US
dc.identifier.issn 0163-3864
dc.identifier.uri http://hdl.handle.net/10311/346
dc.description.abstract The novel phenylanthraquinones 4'-O-demethylknipholone-4'-O-β-D-glucopyranoside (2) and gaboroquinones A (3) and B (4) were isolated from the African medicinal plant Bulbine frutescens. Biaryl 2 represents the first phenylanthraquinone glucoside, while 3 and 4 are the first side-chain-hydroxylated phenylanthraquinones. Their constitutions were determined by spectroscopic analysis, in particular by HMBC, HMQC, and ROESY NMR investigations, and by chemical transformations. The axial configurations were elucidated chemically, by deglucosylation of 2 and by side-chain deoxygenation of 3 and 4 to give the known phenylanthraquinones 4'-O-demethylknipholone (5), isoknipholone (6), and knipholone (1), respectively, and chiroptically, by CD investigations. Compounds 2, 3, and 4 showed moderate to good antiplasmodial and antitrypanosomal activities in vitro. en_US
dc.language.iso en en_US
dc.publisher American Chemical Society. http://pubs.acs.org/jnp/ en_US
dc.subject Bulbine frutescens en_US
dc.subject Gaboroquinones A and B en_US
dc.title Gaboroquinones A and B and 4'-O-demethylknipholone-4'-O-β-D-glucopyranoside, phenylanthraquinones from the roots of Bulbine frutescens en_US
dc.type Published Article en_US


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