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dc.contributor.author Kuete, V.
dc.contributor.author Metuno, R.
dc.contributor.author Ngameni, B.
dc.contributor.author Tsafack, A.M.
dc.contributor.author Ngandeu, F.
dc.contributor.author Fotso, G.W.
dc.contributor.author Bezabih, M.
dc.contributor.author Etoa, F.
dc.contributor.author Ngadjui, B.T.
dc.contributor.author Abegaz, B.M.
dc.contributor.author Penlap, B.V.
dc.date.accessioned 2009-02-13T13:39:32Z
dc.date.available 2009-02-13T13:39:32Z
dc.date.issued 2007
dc.identifier.citation Kuete, V. et al (2007), Antimicrobial activity of the methanolic extracts and compounds from Treculia obovoidea (Moraceae), Journal of Ethnopharmacology, vol. 112, pp. 531–536 en
dc.identifier.issn 0378-8741
dc.identifier.uri http://hdl.handle.net/10311/288
dc.description.abstract The crude extract from Treculia obovoidea was subjected to purification by repeated chromatography. Eight compounds were isolated from Treculia obovoidea and identified as Psoralen (1), Bergapten (2), 7-methoxycoumarin (3), 7-hydroxycoumarin (4), 4,2 ,4 -trihydroxychalcone (5), 4,2 ,4 -trihydroxy-3-prenylchalcone (6), 3-hydroxy-4-methoxybenzoic acid (7) and O-[3-(2,2-dimethyl-3-oxo-2H-furan-5-yl) butyl] bergaptol (8). These compounds together with the extract were tested for their antimicrobial activity against Gram-positive bacteria (six species), Gram-negative bacteria (12 species) and three Candida species using micro-dilution methods for the determination of the minimal inhibition concentration (MIC) and the minimal microbicidal concentration (MMC). The MIC values obtained with the crude extracts varied from 78.12 to 156.25 g/ml against 17 (80.95%) of the 21 tested microorganisms. All the isolated compounds showed selective activity. The antimicrobial activity of this plant as well as that of compounds 6 and 8 is being reported for the first time. The obtained results provide promising baseline information for the potential use of these crude extract as well as some of the isolated compounds in the treatment of bacterial and fungal infections. en
dc.language.iso en en
dc.publisher Elsevier Ireland Ltd. www.elsevier.com/locate/jethpharm en
dc.subject Treculia obovoidea en
dc.subject Moraceae en
dc.subject Compounds en
dc.subject Antimicrobial activity en
dc.title Antimicrobial activity of the methanolic extracts and compounds from Treculia obovoidea (Moraceae) en
dc.type Published Article en


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