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dc.contributor.author Omisore, N.O.A.
dc.contributor.author Adewunmi, C.O.
dc.contributor.author Iwalewa, E.O.
dc.contributor.author Ngadjui, B.T.
dc.contributor.author Adenowo, T.K.
dc.contributor.author Abegaz, B.M.
dc.contributor.author Ojewole, J.A.
dc.contributor.author Watchueng, J.
dc.date.accessioned 2009-02-13T13:00:13Z
dc.date.available 2009-02-13T13:00:13Z
dc.date.issued 2005
dc.identifier.citation Omisore, N.O.A. et al (2005), Antitrichomonal and antioxidant activities of Dorstenia barteri and Dorstenia convexa, Brazilian Journal of Medical and Biological Research, vol. 38, no. 7, pp. 1087-1094 en
dc.identifier.issn 0100-879X
dc.identifier.uri http://hdl.handle.net/10311/284
dc.description.abstract Dorstenia barteri and D. convexa extracts and some isolated components of the former were investigated for effectiveness against Trichomonas gallinarum and compared with quercetin and quercitrin. The antioxidant activity of the extracts/compounds was also determined. The minimum lethal concentrations (MLCs) for the extract of D. barteri leaves and twigs at 24 h were found to be 15.625 and 15.625 μg/ml, respectively. However, the MLCs of the leaf and twig extract of D. convexa were 125 and 437.5 μg/ml, respectively. The prenylated and geranylated chalcones were as active as the prenylated flavones, 6- prenylapigenin and the diprenylated derivative 6,8-diprenyleridictyol. The order of the antitrichomonal activity of the compounds at 24 h was: quercetin (0.121 μg/ml) > quercitrin (0.244 μg/ml) ≥ bartericin B (0.244 μg/ml) > bartericin A (0.73 μg/ml) > stigmasterol (0.98 μg/ml) > 6,8-diprenyleridictyol = isobavachalcone = dorsmanin F (31.25 μg/ ml). D. barteri extracts, quercitrin, and bartericin A, and the prenylated flavonoids had potent antioxidant properties. The twig extract of D. barteri was more potent than the leaf extract. Moderate (EC50 >50 μg/ ml) and high (EC50 <50 μg/ml) antioxidant activities were detected in the leaf and twig extracts of D. barteri and the prenylated flavonoids. Prenylated flavonoids and the isolated compounds with antioxidant properties described here may account for the anti-inflammatory action of these extracts. The antitrichomonal and antioxidant activities shown by the extracts and compounds in this study are consistent with the ethnomedicinal and local use of the Dorstenia species studied. en
dc.language.iso en en
dc.publisher Brazilian Journal of Medical and Biological Research. http://www.scielo.br/scielo.php?pid=0100-879X&script=sci_serial en
dc.subject Dorstenia species en
dc.subject Antitrichomonal en
dc.subject Antioxidant activity en
dc.subject Prenylated flavonoids en
dc.title Antitrichomonal and antioxidant activities of Dorstenia barteri and Dorstenia convexa en
dc.type Published Article en


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