| dc.contributor.author |
Dufall, K. |
|
| dc.contributor.author |
Ngadjui, B. |
|
| dc.contributor.author |
Simeon, K. |
|
| dc.contributor.author |
Abegaz, B. |
|
| dc.contributor.author |
Croft, K. |
|
| dc.date.accessioned |
2008-10-30T10:26:14Z |
|
| dc.date.available |
2008-10-30T10:26:14Z |
|
| dc.date.issued |
2003 |
|
| dc.identifier.citation |
Dufall, K.G. et al (2003) Antioxidant activity of prenylated flavonoids from the West African medicinal plant Dorstenia mannii, Journal of Ethnopharmacology, Vol. 87, pp. 67-72 |
en |
| dc.identifier.issn |
0378-8741 |
|
| dc.identifier.uri |
http://hdl.handle.net/10311/261 |
|
| dc.description.abstract |
The antioxidant activities of three prenylated flavonoids from Dorstenia mannii (6,8-diprenyleriodictyol, dorsmanin C and dorsmanin F)
were compared to the common, non-prenylated flavonoid, quercetin. The prenylated flavonoids were found to be potent scavengers of the stable
free radical 1,1-diphenyl-2-picrylhydrazyl (DPPH), and are more potent than butylated hydroxy toluene (BHT), a common antioxidant used
as a food additive. The prenylated flavonoids also inhibited Cu2+-mediated oxidation of human low density lipoprotein (LDL). Dose-response
studies indicated that the prenylated flavonoids were effective inhibitors of lipoprotein oxidation with IC50 values <1 M and had similar
inhibitory potency compared to quercetin, but was not directly related to Cu binding. Unlike quercetin, they did not show any pro-oxidant
activity at high doses in the Cu2+-mediated lipoprotein oxidation system. The medicinal action of Dorstenia mannii may be related to the
high concentration of potent antioxidant prenylated flavonoids in this species. |
en |
| dc.language.iso |
en_US |
en |
| dc.publisher |
Elsevier Science Ireland Ltd. www.elsevier.com/locate/jethpharm |
en |
| dc.subject |
Low density lipoprotein |
en |
| dc.subject |
Flavonoids |
en |
| dc.subject |
Quercetin |
en |
| dc.subject |
Antioxidant |
en |
| dc.title |
Antioxidant activity of prenylated flavonoids from the West African medicinal plant Dorstenia mannii |
en |
| dc.type |
Article |
en |