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dc.contributor.author Dufall, K.
dc.contributor.author Ngadjui, B.
dc.contributor.author Simeon, K.
dc.contributor.author Abegaz, B.
dc.contributor.author Croft, K.
dc.date.accessioned 2008-10-30T10:26:14Z
dc.date.available 2008-10-30T10:26:14Z
dc.date.issued 2003
dc.identifier.citation Dufall, K.G. et al (2003) Antioxidant activity of prenylated flavonoids from the West African medicinal plant Dorstenia mannii, Journal of Ethnopharmacology, Vol. 87, pp. 67-72 en
dc.identifier.issn 0378-8741
dc.identifier.uri http://hdl.handle.net/10311/261
dc.description.abstract The antioxidant activities of three prenylated flavonoids from Dorstenia mannii (6,8-diprenyleriodictyol, dorsmanin C and dorsmanin F) were compared to the common, non-prenylated flavonoid, quercetin. The prenylated flavonoids were found to be potent scavengers of the stable free radical 1,1-diphenyl-2-picrylhydrazyl (DPPH), and are more potent than butylated hydroxy toluene (BHT), a common antioxidant used as a food additive. The prenylated flavonoids also inhibited Cu2+-mediated oxidation of human low density lipoprotein (LDL). Dose-response studies indicated that the prenylated flavonoids were effective inhibitors of lipoprotein oxidation with IC50 values <1 M and had similar inhibitory potency compared to quercetin, but was not directly related to Cu binding. Unlike quercetin, they did not show any pro-oxidant activity at high doses in the Cu2+-mediated lipoprotein oxidation system. The medicinal action of Dorstenia mannii may be related to the high concentration of potent antioxidant prenylated flavonoids in this species. en
dc.language.iso en_US en
dc.publisher Elsevier Science Ireland Ltd. www.elsevier.com/locate/jethpharm en
dc.subject Low density lipoprotein en
dc.subject Flavonoids en
dc.subject Quercetin en
dc.subject Antioxidant en
dc.title Antioxidant activity of prenylated flavonoids from the West African medicinal plant Dorstenia mannii en
dc.type Article en


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