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dc.contributor.author Chacha, M.
dc.contributor.author Mapitse, R.
dc.contributor.author Afolayan, AJ
dc.contributor.author Majinda, R.R.T.
dc.date.accessioned 2008-09-22T08:13:14Z
dc.date.available 2008-09-22T08:13:14Z
dc.date.issued 2008
dc.identifier.citation Chacha M. et al (2008) Antibacterial Diterpenes from the Roots of Ceriops tagal, Natural Product Communications, Vol. 3, No. 1, pp. 17-20 en
dc.identifier.issn 1555-9475 (online)
dc.identifier.issn 1934-578X
dc.identifier.uri http://hdl.handle.net/10311/224
dc.description.abstract Investigation of the roots of Ceriops tagal led to the isolation of a new isopimarane, together with the known diterpenes isopimar-8(14)-en-15,16-diol and erythroxyl-4(17),15(16)-dien-3-one. The structure of the new compound was identified as isopimar-8(14)-en-16-hydroxy-15-one. These structures were determined from extensive spectroscopic data analysis. The isolates were screened for antibacterial activity using the agar dilution method against ten test bacterial strains (Bacillus cereus, Escherichia coli, Klebsiella pneumoniae, Micrococcus kristinae, Pseudomonas aeruginosa, Salmonella pooni, Serratia marcescens, Staphylococcus aureus, S. epidermidis and Streptococcus pyrogens). Isopimar-8(14)-en-16-hydroxy-15-one exhibited activity, with MIC values of 0.5 mg/mL against Streptococcus pyrogens; 0.25 mg/mL against Salmonella pooni and 0.1 mg/mL against Bacillus cereus, Staphylococcus aureus and Micrococcus kristinae. en
dc.language.iso en en
dc.publisher Natural Product Inc. http://www.naturalproduct.us/ en
dc.subject Ceriops tagal en
dc.subject Rhizophoraceae en
dc.subject Diterpenes en
dc.subject Antibacterial activity en
dc.title Antibacterial Diterpenes from the Roots of Ceriops tagal en
dc.type Article en


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