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dc.contributor.author Keter, F.K.
dc.contributor.author Ojwach, S.O.
dc.contributor.author Oyetunji, O.A.
dc.contributor.author Guzei, I.A.
dc.contributor.author Darkwa, J.
dc.date.accessioned 2012-11-06T07:06:13Z
dc.date.available 2012-11-06T07:06:13Z
dc.date.issued 2009
dc.identifier.citation Keter, F.K. et al. (2009) Bis(pyrazolyl) palladium(II), platinum(II) and gold(III) complexes: Syntheses, molecular structures and substitution reactions with L-cysteine, Inorganica Chimica Acta, Vol. 362, No. 8, pp. 2595–2602 en_US
dc.identifier.issn 0020-1693
dc.identifier.uri http://hdl.handle.net/10311/1032
dc.description.abstract A series of pyrazolyl palladium(II), platinum(II) and gold(III) complexes, [PdCl2(3,5-R2bpza)] {R = H (1), R = Me (2), bpza = bis-pyrazolyl acetic acid}, [PtCl2(3,5-R2bpza)] {R = H (3a), R = Me (4)}, [AuCl2(3,5- R2bpza)]Cl {R = H (5a), R = Me (6a)} and [PdCl2(3,5-R2bpzate)] {R = Me (7)} have been synthesised and structurally characterised. Single crystal X-ray crystallography showed that the pyrazolyl ligands exhibit N^N-coordination with the metals. Anticancer activities of six complexes 1–6a were investigated against CHO cells and were found to have low activities. Substitution reactions of selected complexes 1, 2, 3a and 5a with L-cysteine show that the low anticancer activities compounds and that the rate of substitution with sulfur-containing compounds is not the cause of the low anticancer activities. en_US
dc.language.iso en en_US
dc.publisher Elsevier Science Ltd, www.elsevier.com/locate/ica en_US
dc.subject Bis(pyrazolyl)acetic acid compounds en_US
dc.subject Cytotoxicity en_US
dc.subject Pseudo first-order en_US
dc.subject Substitution en_US
dc.subject L-cysteine en_US
dc.title Bis(pyrazolyl) palladium(II), platinum(II) and gold(III) complexes: Syntheses, molecular structures and substitution reactions with L-cysteine en_US
dc.type Published Article en_US
dc.link http://ac.els-cdn.com/S0020169308006993/1-s2.0-S0020169308006993-main.pdf?_tid=6ba78650-136f-11e2-a410-00000aab0f02&acdnat=1349938184_2795d7e8cd597c5022ef689c82b51682 en_US


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