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dc.contributor.author Mazimba, O.
dc.contributor.author Majinda, R.R.
dc.contributor.author Modibedi, C.
dc.contributor.author Masesane, I.B.
dc.contributor.author Cencicˇ, A.
dc.contributor.author Chingwaru, W.
dc.date.accessioned 2012-08-08T07:58:51Z
dc.date.available 2012-08-08T07:58:51Z
dc.date.issued 2011
dc.identifier.citation Mazimba, O. et al (2011) Tylosema esculentum extractives and their bioactivity, Bioorganic & Medicinal Chemistry, Vol. 19, No. 17, pp. 5225–5230 en_US
dc.identifier.issn 0968-0896
dc.identifier.uri http://hdl.handle.net/10311/1029
dc.description.abstract The investigation of Tylosema esculentum (Morama) husks, cotyledons, and tuber yielded griffonilide 2, compound 1, griffonin 3, gallic acid 4, protocatechuic acid 5, b-sitosterol 6, behenic acid 7, oleic acid 8, sucrose 9, 2-O-ethyl-a-D-glucopyranoside 10, kaempferol 11 and kaempferol-3-O-b-D-glucopyranoside 12. The structures of the isolates were determined by NMR, HR-TOF EIMS, IR and UV–vis spectroscopy, and by comparison with literature data. The husk EtOAc and n-butanol extracts demonstrated >90% DPPH radical scavenging activity at concentrations of 25, 50 and 250 lg/mL. Furthermore the husk extracts showed higher total phenolic content (233 mg GAE/g). The extractives exhibited minimum inhibitory quantities of 50–100 lg or no activity against Staphylococcus aureus, Escherichia coli, Bacillus subtilis, Pseudomonas aeruginosa and Candida albicans. The tuber extracts were inactive against Caco-2 and Hela cell lines, while the husk extracts showed low activity against Caco-2 and Vero cell line with IC50 values >400 lg/mL. The GC–MS analysis showed the beans and tuber non-polar (n-hexane) extracts major constituents as fatty acids. en_US
dc.language.iso en en_US
dc.publisher Elsevier Science Ltd, http://www.elsevier.com/locate/bmc en_US
dc.subject Tylosema esculentum en_US
dc.subject Antioxidant en_US
dc.subject Antimicrobial en_US
dc.subject Cytotoxicity en_US
dc.subject Fatty acids en_US
dc.title Tylosema esculentum extractives and their bioactivity en_US
dc.type Published Article en_US
dc.link http://ac.els-cdn.com/S096808961100544X/1-s2.0-S096808961100544X-main.pdf?_tid=01ee3d9cc1be9b3f62b34bf682f71aec&acdnat=1343896814_388641dc81375d1d90d56898d2ab0bee en_US


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