Browsing by Subject "Bolusanthus speciosus"
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Erasto, P.; Bojase-Moleta, G.; Majinda, R.T. (Elsevier Ltd. www.elsevier.com/locate/phytochem, NaN, 2004)[more][less]
Abstract: Three new flavonoids-5,7,4'-trihydroxy-6-[1-hydroxy-2-methylbuten-2-yl]isoflavone (isogancaonin C), 7,2'-dihydroxy-4'-methoxyisoflav- 3-ene (bolusanthin III), 6,6'-dihydroxy-4'-methoxy-2-arylbenzofuran (bolusanthin IV), in addition to eight known flavonoids; derrone, medicarpan, genistein, wighteone, lupiwighteone, gancaonin C, 7-hydroxy-4'-methoxyisoflavone and 7,3'-dihydroxy-4'- methoxyisoflavone were isolated from the root wood of Bolusanthus speciosus.The compounds showed strong antimicrobial activity against Escherichia coli, Bacillus subtilis, Staphylococcus aureus and Candida mycoderma.The isolated compounds also showed moderate to strong radical scavenging properties against DPPH radical with the highest activities shown by the 2-arylbenzofuran, the isoflav-3-ene and 7,3'-dihydroxy-4'-methoxyisoflavone in decreasing order. URI: http://hdl.handle.net/10311/299 Files in this item: 1
Antimicrobial and antioxidant.pdf (3.228Mb) -
Majinda, R.R.T; Abegaz, B.M.; Bezabih, M.; Ngadjui, B.T; Wanjala, C.C.W.; Mdee, L.K.; Bojase, G.; Silayo, A.; Masesane, I.; Yeboah, S.O. (IUPAC. http://www.iupac.org/publications/pac/, NaN, 2001)[more][less]
Abstract: Marketed plants are very important items of trade in many parts of the world. The community uses these for a variety of purposes such as foods, cosmetics, flavors, spices, and medicines. It seems that plants that are used for medicinal purposes form the most common category. Four plants used for treatment of microbial infections, viz., Bolusanthus speciosus, Erythrina latissima, Crotalaria podocarpa, and Elephantorrhiza goetzei, were investigated, and these yielded several known and novel structures, some with appreciable antibiotic activity against the test organisms. The activity of some of the isolated plants and the parts of the plant from which these were obtained lend support to their traditional use. Bulbine abyssinica and B. capitata yielded phenylanthraquinones, some of which were shown to possess strong antiplasmodial activity. In addition, these yielded isofuranonaphthoquinones, which were also found to be weakly antiplasmodial and antioxidant. Scilla nervosa yielded several known and novel homoisoflavoinds of the 3-benzylchroman-4-ones and 3-benzylidinechroman- 4-one type, as well as some stilbenoids. The homoisoflavonoids showed strong antitumor activity against various cancer cell lines. Rhus pyroides gave a novel bichalcone, which showed weak antifeedant activity, consistent with the observation by farmers that the plant was avoided by corn cricket. Results from investigated Dorstenia species originating from Cameroon, Ethiopia, and Tanzania yielded styrenes, coumarins, chalcones, and flavonoids. The chalcones and flavonoids showed various levels of prenylation or geranylation, and an observation made so far is that prenylated flavonoids are only found in Dorstenia species of African origin. The only example of a bis-geranylated chalcone is found in Dorstenia. URI: http://hdl.handle.net/10311/308 Files in this item: 1
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